The Lake District, settled continuously through history, was called Pisidia. Its boundaries shifted at different times, and the people living in it — the Pisidians — spoke a local language of their own, Pisidian. The language is known from gravestones found at Timbriada in Aksu district, at the village of Sofular and on the Senitli high pasture.

The first settlement in the region goes back to the Upper Palaeolithic and the Mesolithic. In the Neolithic, between 8000 and 5500 BC, this was among the most important cultural regions of Anatolia, and it kept that importance through the Chalcolithic. Material of Chalcolithic date has been found on twelve mounds within the province, and altogether 56 mounds have been identified in Isparta, many of them Bronze Age settlements built over Neolithic and Chalcolithic ones.